Meta-analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility
نویسندگان
چکیده
منابع مشابه
Plasminogen Activator Inhibitor-1 4G/5G Polymorphism Contributes to Osteonecrosis of the Femoral Head Susceptibility: Evidence from a Systematic Review and Meta-analysis
Background: The Plasminogen Activator Inhibitor-1 gene 4G/5G (PAI-1 4G/5G) polymorphism has been suggestedto be associated with osteonecrosis of the femoral head (ONFH) susceptibility; however, the results are conflicting andinconclusive. We have carried out a comprehensive meta-analysis to derive a more precise estimation of the association.Methods: A comprehensive search in PubMed, EMBASE, Go...
متن کاملAssociation between VEGF -634G/C polymorphism and osteonecrosis of the femoral head susceptibility: a meta analysis.
BACKGROUND VEGF plays an important role in bone formation and repair. However, the effects of VEGF -634G/C polymorphisms on the pathogenesis of osteonecrosis of the femoral head (ONFH) were not conclusive. Our research was aimed to further analyze the association of VEGF -634G/C polymorphism with ONFH risk. METHODS The relevant articles were searched in PubMed, Elsevier, EMBASE, Web of Scienc...
متن کاملFrequency of factor V Leiden (G1691A) and prothrombin (G20210A) polymorphisms in Population of Kerman Province, Iran
Background & Aims:Thromboembolism is an acute cardiovascular disease that ranges from clinically unimportant to massive embolism. Both acquired and hereditary risk factors contribute to the disease. We aimed to determine the prevalence of two hereditary predisposing factor of the disease, prothrombin G20210A and factor V Leiden (G1691A) polymorphisms, in Kerman population.<br /...
متن کاملFrequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran
Normal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. Inherited alteration of factor V and prothrombin gene, the G20210A mutation, increases the resistance of factor V to degradation and booster production of prothrombin respectively. These alterations can increase hypercoagulability leading to thrombotic consequences. We aimed to assess the frequencies of ...
متن کاملAssociation of ABCB1 C3435T polymorphism with the susceptibility to osteonecrosis of the femoral head
BACKGROUND AND OBJECTIVE The exploration for the etiology of osteonecrosis of the femoral head (ONFH) has got some promising findings, but the morbidity of ONFH is still not under control. The C3435T polymorphism of ATP-binding cassette subfamily B member 1 (ABCB1) gene has been reported to possess significant influence on ONFH onset, but relevant outcomes remain conflicting rather than conclus...
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ژورنال
عنوان ژورنال: Biomedical Reports
سال: 2013
ISSN: 2049-9434,2049-9442
DOI: 10.3892/br.2013.93